Scientists studying how aging impacts the biological clock’s management of metabolism have found that a low-calorie diet helps maintain these energy-regulating processes humming and the body younger.
In a study appearing Aug. 10 in the journal Cell, Paolo Sassone-Corsi, director of the Center for Epigenetics & Metabolism at the University of California, Irvine, and colleagues show how circadian rhythms – or the body’s biological clock – change because of physiological aging. The clock-controlled circuit which directly connects to the process of aging is based on effective metabolism of energy in cells.
The Sassone-Corsi team tested the same group of mice at 6 months and 18 months, drawing tissue samples from the liver, the organ which functions as the interface between nutrition and energy supply in the body. Energy is metabolized within cells under circadian controls|circadian controls that were precise.
The researchers found that the 24-hour cycle at the circadian-controlled metabolic system of elderly mice stayed the same, however, there were notable changes in the circadian rhythms that turns genes on and off based upon the cells’ energy use. To put it simply, the older|the cells processed energy|energy was processed by the cells that were elderly|the cells that were older processed energy|energy was processed by the older|the cells inefficiently.
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