amyloid plaques

Study reveals early indication of Alzheimer’s in adults with normal cognition

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A brand new research led by the Keck Faculty of Drugs of University of Southern California (USC) reveals that older adults with elevated ranges of brain-clogging plaques, but normal cognition, experience quicker mental decline, suggestive of Alzheimer’s disease. The research revealed in The Journal of the American Medical Affiliation on June 13 introduced the earliest precursor—the toxic and sticky protein as a part of the disease, before symptoms arise.

Alzheimer’s brain: Neuron with amyloid plaques. Credit: Juan Gaertner/

All researchers see amyloid plaques as a danger issue for Alzheimer’s. Nevertheless, this research looked at 10 years of knowledge from the Alzheimer’s Illness Neuroimaging Initiative—an exploration of the biomarkers that signify Alzheimer’s.

“To have the best influence on the disease, we have to intervene towards amyloid, the essential molecular cause, as early as potential,” stated Paul Aisen, senior writer of the research and director of the USC Alzheimer’s Therapeutic Research Institute (ATRI) on the Keck Faculty of Drugs. “This research is a big step toward the concept elevated amyloid levels are an early stage of Alzheimer’s, an applicable stage for anti-amyloid therapy.”

The asymptomatic stage, the incubation interval with elevated amyloid plaques, can last longer than the dementia stage.

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