Skin transplantation might be an effective way to deliver gene therapy to treat type 2 diabetes and obesity, new research in mice suggests.
The technique could enable a wide assortment of gene-based remedies to treat many human diseases.
“We think this can provide a long-term safe option for the treatment of several diseases…”
“We resolved some technical hurdles and designed a mouse-to-mouse skin transplantation model in animals with intact immune systems,” says study author Xiaoyang Wu, assistant professor at the cancer research department at the University of Chicago.
“We think this platform has the potential to lead to safe and durable gene therapy in mice and, we hope, in people, using chosen and altered cells from skin.”
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