Renal denervation superior to ablation in resistant hypertension

SAN DIEGO — Endovascular ultrasound-based renal sympathetic denervation in patients with resistant hypertension was superior to radiofrequency ablation of the main renal arteries, according to data from the RADIOSOUND-HTN trial presented at TCT 2018.

In contrast, a combined approach of radiofrequency ablation of the main arteries, side branches and accessories was not superior to endovascular ultrasound-based renal sympathetic denervation.

“This pilot study precludes definite recommendations regarding the preferable renal denervation approach,” Philipp Lurz, MD, PhD, chief operating officer of the department of cardiology at the Heart Center Leipzig at University of Leipzig in Germany, said during the press conference.

Researchers analyzed data from 120 patients with resistant hypertension, which was defined as an office systolic BP greater than 160 mm Hg or a diastolic BP greater than 90 mm Hg regardless of treatment with three or more classes of antihypertensive medication, which had to be stable for at least 4 weeks. Patients were required to have a systolic daytime BP greater than 135 mm Hg on ambulatory BP measurement and at least one main renal artery with a diameter of at least 5.5 mm to be included in the study.

MRI was also performed to assess the renal artery anatomy. For patients who could not undergo MRI, duplex ultrasound was performed.

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