In a cross-sectional research that used superior imaging methods, tau and Aβ deposits within the brains of elderly, cognitively normal people displayed well-defined hierarchical cortical relationships.
These deposits additionally displayed overlaps between the principal accumulations of both pathologic abnormalities within the heteromodal association areas, the researchers observe.
These findings characterize “systematic, large-scale mechanisms” of early pathologic modifications of Alzheimer’s illness in the elderly human brain, the authors, led by Jorge Sepulcre, MD, PhD, from Massachusetts Common Hospital and Harvard Medical Faculty, Boston, write.
Their report was published online Might 30 in JAMA Neurology.
“We’ve got been speculating concerning the progression patterns of Alzheimer’s disease pathology in the human mind for decades, however a lot of the knowledge that we’ve got come from histology,” Dr Sepulcre advised Medscape Medical News.
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