NSAIDs safe for patients with hypertension, heart failure, CKD

Despite guidelines recommending against the use of NSAIDs in patients with hypertension, heart failure and chronic kidney disease, they are frequently prescribed to such high-risk patients in primary care settings; however, NSAID use was not associated with a higher risk for safety-related outcomes, according to findings published in JAMA Internal Medicine.

“International nephrology societies advise against NSAID use in patients with hypertension, heart failure, or chronic kidney disease (CKD); however, recent studies have not investigated the frequency or associations of use in these patients,” Zachary Bouck, MPH, from the Institute for Health Systems Solutions and Virtual Care, Women’s College Hospital, Toronto, and colleagues wrote.

Bouck and colleagues conducted a retrospective cohort study to determine the frequency of, characteristics of, and variations in prescription NSAID use among high-risk patients. They also evaluated the association between NSAIDs and several cardiovascular and renal safety-related outcomes, including death, cardiac complications, defined as any ED visit or hospitalization for CVD, and renal complications, defined as any hospitalization for hyperkalemia, acute kidney injury or dialysis.

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