Novo Nordisk’s Semaglutide Hits Mark in Type 2 Diabetes Trial

Semaglutide, an oral diabetes drug

Two weeks ago during its quarterly report, Novo Nordisk pointed to positive results in four of 10 Phase IIIa trials with oral semaglutide. This morning, the company revealed that the drug hit the mark in the reduction of blood sugar levels and weight in adults with type 2 diabetes.

In the PIONEER 5 trial, semaglutide, a once-daily oral GLP-1 analog, hits its primary objective of demonstrating statistically significant and superior reductions in HbA1c compared to placebo at week 26. The levels dropped 1.1 percent with semaglutide, compared to the .1 percent reduction on placebo. Using an 8 percent baseline of HbA1c the number of patients who achieved the American Diabetes Association target of 7 percent was statistically significantly greater with 14 mg oral semaglutide. The number of patients who hit that mark was 64 percent after 26 weeks, compared to 21 percent with placebo.

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