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Newly discovered disease mechanism for type 2 diabetes

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IMAGE: This is Anders Rosengren.
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Credit: Johan Wingborg

A newly found mechanism behind lowered insulin manufacturing in sort 2 diabetes is now being introduced. In an article in Nature Communications, researchers at Sahlgrenska Academy describe how insulin-producing cells regress of their improvement, turn into immature, and do not work properly. A discovering that opens the doorways to new medical remedies.

“Should you can have an effect on issues at the mobile degree and restore the physique’s own speedy regulation, you possibly can extra precisely modify blood sugar in contrast to what’s attainable with insulin injections,” says Anders Rosengren, affiliate professor who is lively on the Department of Neuroscience and Physiology in addition to the Wallenberg Centre for Molecular and Translational Drugs on the University of Gothenburg.

It has long been recognized that the insulin-producing cells fail in sort 2 diabetes. The body does not get enough insulin and blood sugar rises. One principle argues that the insulin-producing cells grow to be fewer in quantity, whereas one other argues that their perform is impaired.

The new rationalization, which mixes the debated theories, states that the insulin-producing cells regress of their improvement and turn into immature. This reduces the variety of practical cells.

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