As per the researchers, neurovascular integrity, including cerebral blood flow and blood-brain barrier function, plays a major role in cognitive ability. For the study, the team of researchers examined the effect of diet on cognitive health on mice, which followed a ketogenic diet regimen. Two groups of nine mice, aged 12-14 weeks, were given either the ketogenic diet or a regular diet. The team found that after 16 weeks, mice on ketogenic diet had significant increase in cerebral blood flow, improved balance in the microbiome in the gut, lower blood glucose levels and body weight, and a beneficial increase in the process that clears amyloid-beta from the brain- a hallmark of Alzheimer’s disease.
According to the researchers, while diet modifications, the ketogenic diet in particular, has demonstrated effectiveness in treating certain diseases, the team chose to test healthy young mice using diet as a potential preventative measure.