The mind is vital in the regulation of appetite, body weight and metabolism. Particularly, there is a small group of POMC neurons within the hypothalamus that detect and combine alerts associated to the physique’s power state and activate the appropriate physiological responses. These neurons are sensitive to fluctuations in vitamins comparable to glucose, fatty acids and amino acids.
Now, a analysis undertaking co-chaired by Marc Claret and Antonio Zorzano, each members of the CIBERDEM network, reveals the connection between POMC neurons within the hypothalamus and the release of insulin by the pancreas, and describes new molecular mechanisms concerned in this connection. The research has been revealed in Cell Metabolism.
The connection between hypothalamus and pancreas
POMC neurons detect modifications in nutrient availability, but the molecular mechanisms concerned aren’t recognized intimately. Modifications within the shape of mitochondria, generally known as mitochondrial dynamics, serve as a mechanism of power adaptation in altering metabolic circumstances to adjust the needs of cells.
To determine whether or not defects in the mitochondrial dynamics in the nuclei of POMC neurons might trigger alterations in metabolism, researchers eliminated a mitochondrial protein, Mitofusin 1, in mice.
First, the scientists noticed that these mice had altered detection of glucose levels and adaptation between the fasting and fed states. Second, they found that these defects led to disturbances in glucose metabolism brought on by decreased secretion of insulin.
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