“Using this approach to comprehensively interrogate liver carbohydrate and fat metabolism, we showed that it is a combination of three mechanisms that is responsible for the rapid reversal of hyperglycemia following a very low calorie diet,” says senior author Gerald I. Shulman, professor of medicine and cellular and molecular physiology at Yale and an investigator at the Howard Hughes Medical Institute.
The next step for the researchers will be to confirm whether they can replicate the findings in type 2 diabetic patients undergoing either bariatric surgery or consuming very low calorie diets. His team has already begun applying the PINTA methodology in humans.
“These results, if confirmed in humans, will provide us with novel drug targets to more effectively treat patients with type 2 diabetes,” Shulman says.
Grants from the United States Public Health Service supported this research.