AS is a condition in which the valve that opens and closes when blood is pumped out of the left ventricle becomes narrowed and stiff due to calcium building up. When this happens, the valve fails to work effectively, making it harder for the heart to pump blood to the rest of the body. AR occurs when the valve doesn’t close properly, allowing some blood to leak back into the left ventricle.
During an average follow-up time of more than nine years, 20,680 of the 5.4 million patients in the study were diagnosed with AS alone and 6440 were diagnosed with AR alone. The average age at the time of diagnosis was 64 years and 57 years for AS and AR respectively.
The patients included in this analysis were aged between 30 and 90 years, and none had any known heart or blood vessel diseases at the time of their earliest blood pressure measurement.