Brodmann area 25 may have role in causing peri-ictal systolic hypotension in patients with epilepsy

1. In this case series of 12 patients with intractable epilepsy, deep brain electrical stimulation of Brodmann area 25 resulted in significant and consistent decreases in systolic blood pressure as compared to no blood pressure changes when stimulating any other structure.

2. During Brodmann area 25 stimulation, diastolic arterial blood pressure was maintained thus indicating that the systolic reduction was likely due to decreased sympathetic drive resulting in decreased cardiac output as opposed to bradycardia or peripheral vasodilation-induced hypotension.

Evidence Rating Level: 3 (Average)

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